The work aims to propose an optimal scheme selection method based on AHP and TOPSIS to quantitatively evaluate the sustainability of packaging design scheme.The material, production, transportation, sales, treatment and recycling in the design of packaging products were taken into full consideration to establish a three-level evaluation system of sustainable packaging design scheme. The evaluation model of sustainable packaging design scheme was established by combining AHP and TOPSIS. The judgment matrix was constructed by AHP method, and the weight of packaging design scheme index was determined. TOPSIS method was used to calculate the best set and the worst set of evaluation index to get the order of advantages and disadvantages of different design schemes. Three kinds of sustainable packaging design schemes of the same tea product were analyzed with examples. The superiority of the three design schemes was 0.7182, 0.7503 and 0.2673 respectively. The design scheme of the bag gift box designed by Kraft paper and thickened card paper was the best scheme. The experiment shows that the evaluation model constructed by AHP and TOPSIS can sort the advantages and disadvantages of sustainable packaging design scheme reasonably and efficiently. It provides a useful reference for the optimization of sustainable packaging design scheme.