The work aims to propose a comprehensive evaluation method of cargo palletizing effect from the perspective of industrial application for the problems that there are many influencing factors of aircraft cargo palletizing effect, and the existing evaluation method is too single. Firstly, the cargo tank filling rate, stacking efficiency and center-of-gravity offset were selected as the evaluation indicators. Then, the advantages of the subjective and objective weight assignment method were utilized, and the AHP method and the entropy weight method were combined to obtain the comprehensive weight value of each indicator. Finally, the hierarchical fuzzy comprehensive evaluation model of palletizing effect was established. The example calculation and comparative analysis of 6 cargo palletizing types proved that the 5th palletizing type had the best comprehensive effect, which was consistent with the original information, indicating that the model rationally and reliably evaluated the palletizing effect of aircraft cargo. The proposed model effectively solves the problem of palletizing effect evaluation under multiple factors and provides theoretical basis for palletizing of aircraft cargo.