The work aims to explore the influence of "smart classroom" teaching mode on teaching reform and talent cultivation of professional courses in Colleges and Universities. Taking the course of “Food Additives” as an example, the current situation and existing problems of traditional course teaching were analyzed. The methods of applying the Zhihuishu operation service platform to the course teaching were discussed. The advantages and overall ideas of the "smart classroom" teaching were put forward. Its solutions were expounded, And the reform results were also fed back through questionnaire. The results showed that 61.9% of the respondents thought that the problem analysis ability can be improved through this teaching method, 58.73% thought it can improve the ability of summary and self-learning; 52.38% were more willing to adopt the online and offline teaching, 57.14% thought the distribution of course score was reasonable, and 61.9% of the respondents accepted the teaching mode very much. Practice proves that the "smart classroom" teaching mode can improve students' interest and initiative in curriculum learning, achieve the dual goals of theoretical learning and talent training, which is worthy of application and promotion.