The work aims to analyze the response characteristics of cushion packaging system for eggs under vibration conditions by finite element method to choose the cushion packaging structure, so as to reduce the breakage rate of eggs in distribution. Firstly, the breakage strength of eggs was confirmed by the compression test and the type, frequency and amplitude of vibration were determined by analyzing the distribution environment of eggs. Then, the finite element models of the egg cushion packaging system based on fluid-solid coupled characteristics were established by two cushion structures, with EPS (Expanded Polystyrene) as the cushion packaging material, to analyze the vibration characteristics of two structures under different cushioning thickness. The ultimate breakage strength of eggs determined through compression test was 5.3 MPa, providing evaluation conditions for finite element analysis. The results of finite element simulation showed that the stress of structure I was generally greater than 10 MPa, which was not conducive to protecting eggs, and the stress of structure II was significantly reduced under the same thickness. Structure II with the cushioning thickness＞3 mm could protect eggs from distribution vibration. Finite element simulation can evaluate egg cushion package quickly and effectively to select more beneficial cushioning structure, and improve the safety of egg during distribution.