The work aims to study the environmental impact of sales packaging cartons for cosmetics and optimize the packaging materials and improve the packaging design and production system to achieve green production. Based on the life cycle assessment (LCA) methodology, the eFootprint software and database were used to quantitatively analyze the sales packaging cartons for cosmetics developed and manufactured with white cardboards and polypropylene. The functional unit was a single cosmetics sales carton blank of prescribed size (length 57 mm, width 52 mm, height 60 mm) and structure. The setting of system boundary included the main processes of the carton production and the transportation links of various materials. The life cycle impact assessment was carried out after inventory analysis. Among the nine types of environmental impacts generated by the evaluation objects, GWP, PED and WU contributed a large value. The results of the white cardboards sales packaging cartons for cosmetics were 17.8 g, 185 kJ and 57.8 g, and those of the polypropylene sales packaging cartons for cosmetics were 45.3 kg, 1.16 MJ and 147 g. The energy consumption and environmental impact of the polypropylene sales packaging cartons for cosmetics in the production process were greater than that made of white cardboards, so the preferred material of the two was white cardboards. The types of materials and energy consumption in the production process are the main causes of the environmental impact. The environmental benefits of packaging can be improved by optimizing packaging materials, controlling packaging printing design and improving production system with LCA.