The paper aims to propose a decoupling controller based on active disturbance rejection control (ADRC) for rewinding tension system to ensure the performance of the rewinding tension system in roll to roll printing equipment. Based on the mathematical model and the working principle of the rewinding tension system, the ADRC decoupling controller of the rewinding tension system was designed, and then the proposed controller was simulated in Simulink. Under the same step input, the results showed that the adjusting time of the PID controller was 2.4 seconds, while that of the ADRC decoupling controller was 0.7 seconds. The tension of the rewinding substrate had overshoot and oscillation in the PID controller, but there was no overshoot and oscillation in the ADRC decoupling controller. With the PID controller, the tension fluctuation of the rewinding span was caused by the tension change of the rewinding traction span, while there was no fluctuation in the ADRC decoupling controller. The proposed ADRC decoupling controller is able to realize high precision control of the rewinding tension system and is endowed with better control performance than PID controller.