The work aims to realize the rapid design and rapid verification of filling production line based on virtual simulation technology in view of the design and verification process of filling production line. Firstly, by analyzing the production process of the filling production line, the three-dimensional modeling software SolidWorks was used to model the filing machine, capping machine, labeling machine, inkjet printer, packing machine and other equipment in this production line. Then, the 3D models of all equipment were imported into a simulation software Demo 3D. The action design and motion planning of these models were carried out according to the motion design of the operation flow to construct a virtual simulation system for this filling production line. Finally, according to the requirements of equipment function and production capacity, the mechanical structure of the equipment and the operation speed of the mechanism were adjusted iteratively in the virtual simulation system, and the rapid design and iterative optimization of the filling production line were realized. According to the optimal design of the filling production line, an automatic filling production line was developed. The capacity of the production line was 2400 pcs/h, meeting the requirements of the enterprise. This method can realize the rapid design and rapid verification of the filling production line, shorten the design and development cycle, and reduce the design and verification costs.