Polymethyl methacrylate (PMMA) is a polymer material with good light transmission, weather resistance, electrical insulation and processing properties, but it also has the defects such as high brittleness, poor heat resistance, yellowing and surface scratch. The work aims to improve the defects by forming PMMA with interpenetrating network structure, thus widening the application field of PMMA. The literature analysis was carried out to clarify the synthesis methods of sequential, synchronous, semi, latex, thermoplastics and nanocomposites in detail. Applications of PMMA blending system with interpenetrating network structure in the fields of conductivity, functional film, damping, biomedicine and coating were reviewed. The shortcomings of the current research on IPN PMMA blending system are analyzed, and the application prospect of IPN PMMA blending system replacing traditional transparent materials in the field of packaging and toughened glass in high-rise buildings is put forward.