The paper aims to study the mechanical properties of materials under static load and tensile-tension fatigue loading conditions, and the application of hybrid fiber composites in packaging boxes and other fields. Five types of hybrid fiber composites for packaging boxes prepared by resin transfer molding were tested for tensile properties and tensile-tensile fatigue properties. The tensile strength of the pure C sample was higher than that of the C/G layer and the C/G interlayer. Under the same layup and weaving method, the tensile strength of the sample in the C/G layer was higher than of the C/G interlayer sample; the plasticity of the pure G sample was significantly higher than that of the C/G layer and C/G interlayer samples, and the elongation of the C/G layer samples after breaking was higher. In the C/G interlayer sample; the C/G layer sample had a hybrid positive effect, which can ensure good plasticity while having high strength. The role of glass fiber in improving the fatigue life of composite materials was higher than that of aramid fiber. The former had lower stiffness degradation than the latter, and the inter-layer hybrid method of carbon fiber and glass fiber was better than inter-layer hybrid. The composite had a positive hybrid effect when resisting fatigue damage.