The work aims to evaluate the safety and economy of food packaging scientifically and systematically, and solve the problem that food packaging pays more attention to design than safety evaluation, so as to ensure the safety of food packaging and extend the shelf life. Based on the qualitative analysis of the impact of food packaging elements, packaging technique, packaging technology and circulation environment on food safety, a fishbone diagram of causal relationship affecting food safety was established. The method of correlation matrix was used for quantitative analysis of food packaging system. Taking milk packaging as an example, three different packaging methods were selected for milk packaging, and the quantitative calculation of different packaging systems was carried out by the method of correlation matrix. According to the system evaluation results, the evaluation quantitative of Tetra Pak brick milk, plastic bottle and pasteurized baler were 5.0, 3.7 and 2.6 respectively. The safety difference of each food packaging system could be directly reflected through the system evaluation quantitative. The qualitative and quantitative evaluation of the system through causality and correlation matrix can provide strong data and theoretical support for the construction of food packaging safety system.