The work aims to study the cushioning characteristics of honeycomb paperboard under multiple impacts with varying amplitudes, so as to provide a reference for the transport packaging design of honeycomb paperboard. The honeycomb paperboard was subjected to multiple impacts of different strengths to simulate the impact and drop experienced during actual transportation and then the quasi-static compression test was performed to evaluate the change of its cushioning performance. After multiple impacts, the remaining structure of the honeycomb exhibited two distinct deformations. The uncrushed portion with vertical cell walls and the wrinkled crushed portion caused by the accumulation of impacts showed that, the impact strength from low to high had a more obvious effect than that from high to low on the stress-strain, cushioning coefficient and energy absorption curves of the honeycomb structure, and the degree of influence increased with the increase of the height type. Multiple impacts will adversely affect the cushioning performance of the honeycomb paperboard, and the degree of influence will be affected by the impact order. Therefore, considering the type of impact is of great significance for cushioning packaging.