The work aims to study the fatigue damage of packaging system caused by different vibration and impact during product transportation in the current logistics transportation environment. In view of the transportation environment simulation of the packaging system with polystyrene foam as the cushion packaging material, the finite element analysis software was used to simulate the random vibration of the packaging system in the transportation environment, so as to obtain the weak part of the packaging system. The fatigue simulation of the weak part was conducted to obtain its damage data. The simulation results showed that, the package could protect the product in the actual transportation process, and provide guidance for the packaging transportation scheme of the product. The proposed method is not only applicable to the packaging system herein, but also can be used to evaluate the packaging schemes of common household appliances.