The work aims to design the transport packaging of flat glass with the polyurethane foam pad of corrugated box and verify the rationality and feasibility of the design through simulation analysis. The model of transport package was built with Creo parametric software and analyzed with Ansys Workbench software to complete the static stacking load, modal and random vibration simulations. In addition, LS-DYNA and Ansys Workbench were jointly used to simulate the dropping. The simulation results of transport packaging forms of corrugated box and wooden box were compared and analyzed to obtain the result that the maximum response stress of corrugated box was the minimum and uniformly distributed under the same static stress. In the process of random vibration, although the deformation of corrugated box was larger than that of wooden box, it was required to avoid stress concentration and meet the requirements of deformation limit. During the dropping, the force of corrugated box was less than that of wooden box transmitted to flat glass and the stress concentration was avoided. The comprehensive analysis on the results shows that, the transport packaging form of corrugated box with polyurethane cushion is designed reasonably and can better protect the safety of flat glass during transportation. The proposed design solution is feasible.