The work aims to study the distribution of air nozzles, in order to improve the drying performance of packaging printing equipment. The distribution model of air nozzles was established and the unstructured meshing was conducted with reference to the air nozzle of actual packaging printing equipment. The boundary conditions and governing equations suitable for the air nozzle were chosen based on the actual situation. The spacing between the air nozzles and the distance between the substrates were taken as the main parameters and controlled, and a mathematical model was established to describe the relationship between the air nozzle parameters and the performance of hot air fields. The drying effect of different parameter models was estimated based on the mathematical model established. The influence of such parameters as the spacing between the air nozzles and the distance between the substrates on the distribution of hot air field was obtained according to multiple simulation experiments. The corresponding empirical formula was described as . The spacing between the air nozzles had a remarkable influence on the air nozzle drying. The increased spacing between the air nozzles could improve the speed to dry the air nozzles and the uniformity of hot air field. Meanwhile, the speed of air on the substrate increased when the substrate continued moving forward and under the action of the air nozzles. Through research and analysis, the distribution law of hot air field under different parameters has been mastered, which provides important reference value for guiding the design of air nozzle drying in the actual production.