The work aims to study the influence of the content of montmorillonite and micro fibrillated cellulose (MFC) on the barrier properties of the coating film by coating, in order to improve the barrier properties of the polypropylene film. With montmorillonite and MFC as the main raw materials, the adhesives, thickeners and dispersants were added to prepare a coating and apply it on the biaxially oriented polypropylene (BOPP) film. The film's oxygen permeability, water vapor permeability, infrared spectrum annalysis, XRD analysis and thermal stability analysis were used as evaluation criteria to characterize and analyze the film's properties. When the mass fraction of montmorillonite was 2% and the mass fraction of MFC was 0.5%, the oxygen permeability coefficient of the two-component coating film reached the lowest, which was 97% lower than that of the polypropylene film. When the mass fraction of montmorillonite was 2% and the mass fraction of MFC was 0.3%, the water vapor permeability coefficient was the lowest, which was 22% lower than that of the polypropylene film. XRD showed that, when the mass fraction of MFC was 0.5%, the intercalation structure was the best. The thermal stability analysis showed that, the two-component coating film had the best thermal stability when the mass fraction of montmorillonite was 2% and the mass fraction of MFC was 0.5%. The comprehensive analysis concludes that the application of two-component coating added with montmorillonite and MFC can effectively improve the barrier properties of the polypropylene film.