The work aims to carry out a research on water-based ink cleaning agent, in order to improve its environmental protection and stability. On the basis of analyzing the cleaning mechanism of the cleaning agent, a variety of surfactants were selected for compounding experiment to determine the surfactant compounding formula and proportion. The ratio experiment was used to determine the preparation process parameters of auxiliary agents, such as detergent and rust inhibitor. Then, the design formula of ink cleaning agent was optimized to determine the preparation process route of water-based ink cleaning agent, through the compounding experiment of surfactant and auxiliary agent. The optimal formula was obtained: 82 g water, 9 g AES, 2 g AEO-9, 2 g sodium chloride, 1 g sodium silicate, 1 g benzotriazole, 2 g urea and 1 g triethanolamine. The cleaning force, corrosion and rust resistance of the ink cleaning agent reach the specified standards, so that the water-based ink cleaning agent with stable performance can be prepared.