The work aims to screen out five influencing factors of packaging paperboard's light-fastness test in the test chamber and verify the method stability. The test chamber equipped with a filter xenon arc light was used to simulate the spectral energy distribution in the ultraviolet region of the sunlight. The exposure conditions were adjusted to simulate the daily use environment of packaging paperboard and its products. The exposure factors were analyzed by response surface analysis, and the chromatic aberration light fastness of the printing ink of the sample was evaluated by color difference meter. The optimized exposure conditions of test chamber were (65±1.0)℃ blackboard temperature, (45±1.0)℃ air temperature, (50.0±2.0)% air relative humidity, 340 nm light wavelength, 0.30 W/m2 light irradiance and 42 h exposure time. The printing ink chromatic aberration ΔE*ab of artificially exposed samples was measured by the color difference meter. The validation test shows that the proposed method is reliable and stable, which provides analytical and testing technical support for further standardizing the quality supervision of packaging paperboard and its products.