The work aims to study and design a mobile telecontrol smart medicine box based on WiFi technology, re-garding the problem that people usually forget to take medicine, repeatedly take medicine and take wrong medicine when they are ill. STM32 MCU was used as the control core in the system. The small squares in the medicine box were under directional movement through the control over the motor, and the designated drugs were moved to the designated position. Hall sensor was used to detect whether the drugs were taken or not. The LCD screen was used to select the functions and display the drug information, and the clock chip was used for timing. The proposed system could realize the functions of regular reminder, quantitative prompting, fixed-point broadcasting, information setting and storage. At the same time, it synchronized the medicine box data information with the mobile APP information through WiFi communication module, which facilitated the mobile telecontrol and realized the communication function. The proposed system can remind patients of taking medicine in time, and greatly reduce the occurrence of forgetting to take medicine, repeatedly and mistakenly taking medicine and so on. Smart medicine box is flexible in configuration, simple in operation, humanized in design, suitable for all kinds of people, and has great market application value.