The work aims to research and solve the low strength problem of flower transport packaging box. The paper angle guards were pasted in the four side corners of the box body, adjustment blocks with slots were pasted on the inner side of the box body, and vertical partitions and horizontal stratified partitions were installed on the adjustment blocks. The paper angle guards were installed in four side corners of the box body, which improved the supporting force of the multi-layer stacking of the packaging box. Installation of vertical partitions and horizontal stratified partitions enhanced the longitudinal and transverse internal stress of the box body and improved its overall packaging strength. At the same time, the large space inside the box was divided into several small spaces through structural design, which was conductive to the classification and packaging of different flowers, and to a certain extent, inhibited the "extrusion" packaging. The packaging box after structural design is subject to the stress test based on the software simulation. After that, its compressive performance is significantly improved. As the proposed packaging box can effectively reduce loss rate of the flowers and improve economic efficiency, it has good market application value.