The paper aims to improve the ink-jet printing quality of water-based ink, and obtain good ink droplet shape by controlling the process parameters of ink-jet printing. The key parameters of ink-jet printing process control and the characterization parameters of ink droplet morphology were analyzed. The influence of voltage, ignition frequency and pulse width on the evaluation indexes of ink droplet morphology was analyzed through the experiment of single factor process parameters on ink droplet morphology. The quality analysis model of ink droplet morphology was constructed by AHP method. The orthogonal experiment of the influence of multi-factor process parameters on the combination of ink droplet morphology was carried out. The correlation between the process parameters and the morphological parameters of ink droplets was analyzed, and the influence of the process parameters on the morphology of ink droplets was comprehensively evaluated with the quality evaluation model. Voltage, ignition frequency and pulse width jointly affected the quality of ink droplets. Pulse width had the greatest influence on the quality of ink droplets, followed by ignition frequency and voltage, with weights of 0.462, 0.272 and 0.266, respectively. In the waterborne ink ink-jet printing process, the shape quality of ink droplets can be effectively improved by controlling the key parameters of the ink-jet printing process reasonably, and good printing quality can be obtained.