The work aims to study the cargo space distribution of the warehouse, in order to improve the efficiency of cargo storage and turnover in the warehouse integrated with storage and distribution. Based on the FMCG (fast moving consumer goods) distribution center warehouse integrated with storage and distribution in northwest China, the theory of polychromatic sets was applied to establish the cargo space information model in the proposed warehouse. Through the simulation experiment of the established model with actual cases, the optimal partition of cargo space in the warehouse was obtained. As a result, the waiting time of the vehicle in the warehouse based on the principle of the nearest cargo placement and cargo partition management was simulated, and it was limited to 100 days. It was concluded that, the waiting time for loading and unloading of vehicles in the warehouse with partitions based on the theory of polychromatic sets was 20.84% lower than the previous unpartitioned time. The theory of polychromatic sets is used to effectively improve the efficiency of cargo space optimization in the integration of storage and distribution of urban FMCG.