The work aims to design an automatic blister medicine packaging production line. By analyzing the production process of blister medicine packaging, the three-dimensional modeling and assembly of each structure was carried out with Solidworks software. With Schneider’s LMC058LF42 PLC as the control core, the coordinated operation of the entire production line was controlled in collaboration with other hardware devices, in order to realize the automatic production of medicine blister packaging. The actual operation of the blister packaging production line was stable, and the finished products were qualified to meet the company's requirements. The proposed packaging production line has achieved the automatic production of various forms of tablets and capsule blister packages, which reduces production costs and increases the efficiency of pharmaceutical packaging production.