The work aims to analyze the influence factors of dynamic and static friction coefficients of cigarette printing during production, so as to improve the production efficiency. Under different process conditions and different paper substrates, the cigarette prints with different production numbers in the same batch were randomly selected, and the dynamic and static friction coefficients of the main printing surface were measured by MXD-01 friction coefficient meter. On the same substrate, the static friction coefficient of the water-based varnish on the surface ranged from 0.375 to 0.405 and the dynamic friction coefficient ranged from 0.230 to 0.245. The static friction coefficient of the UV varnish on the surface ranged from 0.350 to 0.375 and the dynamic coefficient ranged from 0.185 to 0.220. Under the same process conditions, the optimal drying time was 2 hours, the static friction coefficient of the cigarette sample was stable at 0.380~0.400, and the dynamic friction coefficient was stable at 0.215~0.23. Under the same detection condition, the static friction coefficient of white card paper ranged from 0.615 to 0.630 and the dynamic friction coefficient ranged from 0.470 to 0.505, while the static friction coefficient of silver cardboard ranged from 0.560 to 0.595, and the dynamic friction coefficient ranged from 0.430 to 0.465. Through comprehensive analysis, drying time, varnish drying mechanism and paper characteristics all affect the friction coefficient of cigarette printing.