The paper aims to study the application of ergonomics in pharmaceutical packaging machine to meet the requirements of packaging equipment in safety, convenience and amenity. First of all, based on ergonomics, the paper an-alyzed the existing structure design and operation mode of the pharmaceutical packaging machine and other man-machine problems to have in-depth analysis on shape and printing cam structure of the pharmaceutical packaging machine. Secondly, the method of fuzzy mathematics was adopted to set up an evaluation system for the ergonomics design of the above-mentioned drug packaging machine. Through determining each order weight and the membership degree set by the expert method, a systematic and comprehensive fuzzy evaluation was made for the drug packaging machine, and the evaluation result was 0.762, which met the design requirements and purposes of the drug packaging machine. Through combination of ergonomics and fuzzy mathematics, the design of pharmaceutical packaging machine and other equipment can be well evaluated.