The work aims to study the system optimization problem of the express delivery packaging recycling system in universities in consideration of enterprise benefits, so as to improve the environmental pollution caused by express packaging in university campuses. According to the recycling characteristics of express delivery packaging in university campus, the packaging recycling mode recovered by third-party enterprises was applied, and the packaging damage rate was introduced to classify and recycle the packaging. Considering the influence of regeneration benefit on the recycling system, the express packaging recycling model under the campus environment was established by system dynamics. Further, from the average weight of express packaging and the level of cooperation between schools and enterprises, four different simulation schemes were designed, and the model was verified by Vensim PLE simulation software, and the main factors affecting the recycling effect of express packaging were analyzed, and the sensitivity analysis of the main influencing factors was carried out. The example verification showed that only reducing the average weight of express packaging was not obvious for the improvement of the status of express delivery packaging in colleges and universities. By increasing the influence factor of school-enterprise cooperation level, simplifying express packaging, and enhancing students' environmental awareness, the amount of discarded packaging and waste packaging in the campus could be reduced, the recycling efficiency of enterprises was obvious, and the cooperation between schools and enterprises was closer. Increasing the level of school-enterprise cooperation can significantly improve the recycling effect of express packaging and improve the efficiency of enterprises, and reducing the average weight of packaging can effectively control the cumulative rate and landfill volume of abandoned packaging in campus, which is of great significance to the development of environmental logistics.