The work aims to explore the causes of wrinkles, scratches and slippage of the web when it passes through the guide roller in the roll-to-roll manufacturing process of flexible electronic web, in order to improve the manufacturing precision and efficiency of flexible electronic web. The research progress of the flow field characteristics of the air entrainment between the guide roller and web and traction characteristics of the web on guide roller in recent years were summarized, and the key points for further study were presented. The flow field characteristics of the air entrainment between the web and the guide roller and the traction characteristics of the web on the guide roller were the main factors affecting the stable transmission of flexible electronic web, which played an important role in improving the machining precision of flexible electronic products. The effective control of the flow field characteristics of the air entrainment and the traction characteristics of the web on the guide roller are helpful to improve the precision of the web transmission, so as to ensure the production quality of flexible electronic products manufactured by roll-to-roll process.