The work aims to propose a stability calculation method regarding the problem of determining the stability of strong heterogeneous stack type. Firstly, statics and dynamics analysis was carried out to establish the physical model, five stability parameters were quantified, and the indicators (vertical stability and horizontal stability) for quantitatively evaluating the stability of stack type were defined. Then, the central skeleton algorithm, the branch and bound algorithm, Extreme Point algorithm were respectively used to establish the simulation stack type, compare the spatial layout position and layout effect of goods, obtain the vertical stability and horizontal stability by calculation formula, and analyze the mechanism of the stability of the stack type. Finally, the small-scale carton experiment was carried out to further verify the rationality of the formula. The stability calculation formula proposed herein could be effectively used for the stability evaluation and analysis of strong heterogeneous stack type. The method has certain reference value for improving the engineering applicability of the palletizing algorithm, enhancing the safety of air baggage trimming, and preventing the cargo from falling down in the ground transportation process.