The work aims to prepare the flexible water-based ink specially for instant ticket with excellent performance, and study the factors influencing scraping performance of the ink. The type of resin, and the types and ratios of wetting agent and emulsion in the ink formula were changed respectively to prepare the ink, and the scraping performance of the ink on the isolating oil was tested. The influencing factors of scraping performance of water-based ink for instant ticket were explored. Joncryl 678 was selected as the grinding resin, and the scraping performance of the ink was better. When the wetting agent was TEGO wet245 and its mass fraction was 4%, it could ensure better comprehensive scraping performance under the premise of normal inking. When Neocryl A-1120 was selected and its mass fraction was 50%, the scraping layer could be effectively scraped, and the ticket sample could be scraped normally after aging. Based on comprehensive consideration of the interaction of various factors, when the mass fraction of wetting agent 245 was 4% and the mass fraction of emulsion A-1120 was 50%, the comprehensive scraping performance of ink was the best. The grinding resin in the ink formula has certain influence on the scraping performance of the ink. The type and content of wetting agent have great influence on the scraping performance of scraping ink. Among them, the wetting agent also affects the ink application on the UV varnish backing sample sheet. Due to the particularity of instant ticket, it is necessary to comprehensively consider the covering property and scraping performance, and finally reasonably select and add the wetting agent. Emulsion plays a decisive role in the scraping performance of ink layer in ink formula. The interaction between the types of wetting agent and emulsion, between the contents of wetting agent and emulsion has a great influence on scraping performance of the ink. For the evaluation of the influencing factors of scraping performance, the interaction between components should be considered.