The work aims to effectively avoid or reduce the redeposition and adsorption of water-based ink particles onto fibers due to excessively small particles by enhancing their particle size during the recycling process of this kind of wastepaper, and also improve the removal efficiency for the water-based ink of small particles during the wastewater treatment, as the paper-based packaging materials are printed mostly with water-based ink. The change in particle size of water-based ink of small particles in the wastepaper repulping system was simulated under different additives and pH values. Adding a certain amount of organic additives CaCl2 and CTAB or adjusting the pH in the system could increase the particle size of water-based ink particles without fibers. However, there was no good effectiveness for the addition of CTAB with fibers. The particle sizes of water-based ink particles are relatively larger (3.8, 1.0, 0.5 μm respectively), when the pH value of the system is 5 and the concentrations of CaCl2 and CTAB are 0.20 mol/L and 0.12 mmol/L, respectively. However, with the presence of fibers, the effectiveness is decreased after adding CaCl2, the optimal concentration is 0.30 mol/L and the particle size is 2.7 μm. For CTAB with fibers, it cannot promote the flocculation of water-based ink and but instead reduces the optical properties of paper pulp.