In view of the non-linearity and large lag of the temperature control system for the thermal sealing cutter of the packaging machine, the effect of traditional PID control is increasingly unable to meet the requirements of process production. The paper aims to improve the temperature control speed and accuracy of the thermal sealing cutter for the packaging machine to increase the sealing quality as well as the packaging efficiency and the quality of products. Based on traditional PID control, a temperature control system of hot-sealing cutter of packaging machine based on fuzzy internal model -PID control algorithm was proposed by combining the advanced control algorithm of fuzzy control and internal model control theory. The internal model control can simplify parameters of the PID controller, and the introduction of fuzzy control can realize online adjustment of controller parameters. The new control algorithm was applied to the temperature control system for the heat sealing cutter of the packaging machine and compared with the traditional control. The simulation platform of temperature control system for hot-seal cutter of packaging machine controlled by internal model-PID was built with the Matlab simulation software. Compared with the traditional temperature control system, the simulation system had better performance in response speed, precision, overshoot, anti-disturbance ability, etc. The validity and feasibility of the fuzzy internal model-PID control in the temperature control system of the heat-sealing cutter are verified by simulation. It can show a strong performance index in the temperature control system.