The work aims to optimize the synthetic process conditions of epoxidized soybean oil acrylate (AESO). AESO was synthesized with epoxidized soybean oil and acrylic acid by adding anthraquinone as catalyst, p-methoxyphenol as inhibitor. The reaction was completed with acid value as indication. The reaction product was dissolved and precipitated by butanone and ether. Then AESO was refined at the end of the purification. The effects of the ratio of epoxidized soybean oil to acrylic acid, the consumption of catalyst and inhibitor on the reaction and product were studied. When ratio of epoxy soybean oil to acrylic acid (mass ratio of epoxy and carboxyl nepoxy∶ncarboxyl) was 1.12∶1, the mass fraction of catalyst was 1.2% (mass fraction) and the mass fraction of the inhibitor was 0.10% (mass fraction), the viscosity of AESO was 47.31 mPa•s, and the acid value was 4.73 mg/g (in the mass of KOH). AESO was transparent liquid with glossiness of 2±1 and brightness of (90±5)%. Excessively high amount of epoxy group will decrease the viscosity of the product. Excessively high amount of catalyst will decrease the viscosity and acid value of the product. Gloss and brightness of synthetic resin are higher, conforming to the standard on resin for printing ink.