The paper aims to improve the conductivity of the organic material on the paper substrate. With organic semiconductor material Poly (3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT/PSS) as conductive materials, different papers (glassine paper, offset paper, copy paper, and inkjet paper) were used as the substrate, PEDOT/PSS solution was doped with dimethyl sulfoxide (DMSO) and isopropanol (IPA) binary solvent. The conductivity of PEDOT/PSS coating on paper was compared and analyzed. At the same time, the effects of single concentration coating, falling concentration coating and rising concentration coating on the conductivity of the coating were discussed. When doping a single solvent DMSO in PEDOT/PSS solution, the best conductivity can be achieved by adding 5% DMSO. The PEDOT/PSS solution was optimized on the paper by doping binary solvent. The optimal volume fraction was 23%. At the same time, the coating of inkjet paper had the best conductivity under different concentration formulas. Multi-layer coating of falling concentrations could reduce the coating resistance from 13 kΩ/□ to 0.255 kΩ/□. Doping with binary solvent can greatly improve the electrical conductivity of PEDOT/PSS conductive coating. Paper of dense surface, good smoothness and low permeability is the best choice of substrate. The best way is a multilayer falling concentration coating.