The paper aims to optimize the structure design of LCD TV packaging foam to improve its impact resistance and reduce its packaging costs. The finite element model of the LCD TV with packaging was built with HyperMesh and the validity of the model was verified. According to the drop test standard of enterprise, drop test simulations were conducted with LS-DYNA, and OptiStruct was used to perform topology optimization based on the simulation results. Finally, the results before and after optimization were compared. In the drop test simulations, the acceleration peaks of LCD TV were the highest in the front and back drop conditions, which were 220.01 g and 183.40 g, respectively. After optimization, the peak accelerations of the LCD TV in all conditions were decreased, and the back drop condition was the most, which was 23.41%. At the same time, the optimized structure was 6.73% lighter than the original structure. The structure optimization of the packaging foam effectively improves the safety performance of the LCD TV during the drop impact and reduces the production cost.