This paper aims to summarize the application and research progress of information technology in printing and packaging anti-counterfeiting. The application and research progress of information technology in printing and packaging anti-counterfeiting was introduced in details according to existing literatures. The printing and packaging anti-counterfeiting mechanism and application cases combined with intelligent label, network communication technology and digital image processing technology wereintroduced emphatically. The application of the combination of radio frequency identification system and anti-counterfeiting was analyzed. Then it introduced the application research of anti-counterfeit printing and packaging based on mobile Internet and communication technology. Finally, the application of printing packaging anti-counterfeiting based on image processing technology was introduced, and the application field ofinformation technology in printing and packaging anti-counterfeitingwas expanded. With the rapid development of modern science & technology, the enhancement of market demand, and people's awareness of anti-counterfeiting, the improvement of anti-counterfeiting technology has become an inevitable choice. New anti-counterfeiting technology combined with printing and packaging will continue to be intelligent and popular. With the rapid development of advanced intelligent information technology, the application potential of information anti-counterfeiting is huge and the application prospect of information anti-counterfeiting inprinting and packaging is very considerable.