The work aims to develop valve-less ceramic pump with high precision and cleanliness by utilizing characteristics of zirconia ceramics such as high strength, high hardness, scratch and abrasion resistance and corrosion resistance, because the traditional plunger pump has complex structure and poor filling stability, what can no longer meet the high-end aseptic precision filling requirements of high temperature and corrosion resistance. By changing the traditional plunger mode, a new valve-less structure was designed to make the ceramic plunger rotate circumferentially and move axially in the ceramic cylinder at the same time, and the liquid pressure difference was obtained. The relationship model between pressure and flow was established. The realization methods of flow control and precision fine-tuning were put forward for the valve-less rotary pump. The processing technology of cylinder barrel manufactured by grinding rod and the processing method of ensuring high assembly accuracy were analyzed. When the filling range was 6 mL/r, the highest filling accuracy could reach 0.42%. Valve-less zirconia ceramic pump of high performance was obtained. The developed valve-less zirconia ceramic pump has a large filling range and high filling accuracy. It is suitable for the high-end aseptic precision filling industry with high temperature and corrosion resistance.