The work aims to improve the speed, accuracy and stability of measurement control system of packaging machine so as to achieve the fast and accurate product packaging because the measurement control system of powder packaging has the non-linearity and traditional PID control can not meet the performance requirements of industrial product packaging. On the basis of the existing control theory, combining the theory of fuzzy control and the principle of hormone regulation of biological neuroendocrine glands, a powder packaging metering control system based on Fuzzy short feedback PID control was proposed. The introduction of fuzzy control could realize on-line adjustment of parameters of traditional PID controller. The introduction of short feedback algorithm could make the fuzzy PID control more accurate and fast. The new control algorithm was applied to the quantitative control system of powder packaging to be compared with the traditional control. Simulink toolbox in Matlab was used to build a simulation platform of powder packaging metering control system based on Fuzzy short feedback PID control. Compared with traditional PID control and fuzzy PID control, the system had fast response speed and strong anti-interference ability. The simulation results show that the powder packaging metering control system based on Fuzzy short feedback PID control has good stability, fast response and other good performance indicators, and has a certain anti-interference ability.