The work aims to study the material distribution mode of the shortest path-oriented industrial packaging production line under the condition of time cost. Firstly, the problems of waste of resources and duplication of routes in material distribution of industrial packaging production line of the company were studied. The layout chart of material distribution in industrial packaging production workshop was given, and an optimization model for material distribution in industrial packaging production line was established. The model was solved by simulated flow algorithm. At the same time, the method was compared to the conventional method for analysis. The data obtained by computer showed that the simulated flow algorithm not only reduced the number of iterations, but also significantly shortened the computing time compared with other similar ant colony algorithm. The superiority and validity of the model and algorithm are obtained by comparing and analyzing the examples. The distribution mode of loading and unloading route can be automatically generated by computer in the actual production of enterprises to save the cost of manual guidance.