The paper aims to have systematic research on the design method and law of barrier structure packaging, to provide a way to solve the safety of packaging use and the security of commodity anti-counterfeiting. Through combing and analyzing existing references and related patents at domestic and abroad, the concept and characteristics of barrier structure packaging and the design forms of obstacle elements were clarified. Combined with case study, its key links and design keys in design were con-cluded. The barrier structure packaging could restrict the use behavior of the target group through the internal obstacle structure, so as to provide certain anti-counterfeiting and protection functions for the contents while protecting the safety of a specific group of people. According to different protection requirements, the barrier structure is mainly divided into two types: absolute restriction and conditional restriction. In specific design, it is necessary to pay attention to appropriate selection of obstacle elements, effective activation of protection functions, rational application of reverse thinking and other key problems. A design prospect for the shortcomings of the current obstacle structure packaging is made.