The paper aims to protect the optical color of liquid crystal from external erosion, so that liquid crystal can be used in industry twice to achieve multi-shell microcapsule coating. Different types of organic compound capsule materials (wall materials) were used, and multi-shell liquid crystal microcapsules were produced by the interaction of different kinds of polymerization methods such as emulsion, grafting and solution. The first shell was made of two hydrophilic colloids with different charges, the second shell was made of polymers formed by transparent organic compounds monomers as wall materials, and an alloy transition layer of interpenetrating polymer network was constructed between the first shell and the second shell. The encapsulation of multi-shell liquid crystal microcapsules with particle size of 12 μm was successfully completed. The color change can be effectively presented and the structural strength met the printing requirements. The microcapsules developed have 3 layers of structure. They are strong, acid and alkali resistant, not susceptible to environmental impact, and can effectively protect the unique optical brilliance of liquid crystal. They can be used in industrial products for a second time and achieve the desired research objectives.