The paper aims to establish a method for simultaneous determination of 12 non-phenyl ester plasticizers in cigarette packaging materials by GC-MS-SIM to determine the content of non-phenyl ester plasticizers in cigarette packaging materials. The target substance in the cigarette packaging material was extracted by shaking with dichloromethane solution as the solvent, and ana-lyzed by GC-MS-SIM, and then quantified with benzyl benzoate as the internal standard. The results showed that the method had good linearity in the range of 0.001~0.200 mg/g, the determination coefficient R2>0.999, the detection limit range was 1.2~7.2 μg/g, the recovery rate of 12 non-phenyl ester plasticizers was between 90.63% and 102.99% (RSD=0.71% to 5.37%, n=5). This method was used to determine the 12 kinds of cigarette packaging materials collected, five kinds of non-phenyl ester plasticizers were detected, and their content ranges were DEA (0~0.0200 mg/g), TBP (0.1699~0.1783 mg/g), TPP (0~0.021 mg/g), ATBC (0.0062~9.0358 mg/g), TBC (0~0.0198 mg/g). The method is easy to operate, has high sensitivity, can meet the requirements of fast and accurate analysis, and is suitable for detection and analysis of non-phthalate plasticizer content in packaging materials for cigarettes.