The paper aims to study the optimal concentration and time parameters of SO2 pulse fumigation anticorrosion to solve the problems of preservative phytotoxicity, water loss, granulation and decay of red grape. With Xinjiang Red Grape as test material, pulsed anti-corrosion equipment was applied to accurately and quantitatively control the experimental process. The effects of different pulse preservative methods on physicochemical indexes such as titratable acid, conductivity, mass loss rate and polyphenol oxidase activity during red grape storage were studied. The best way for anti-corrosion of red grape was to fumigate for 30 min for the first time with SO2 at concentration of 1%, and then fumigate for 30 min at 0.2% every 15 days. This fumigation method could effectively inhibit the consumption of organic acids during storage of red grapes, maintain cell membrane integrity, and inhibit metabolism, rot and fall. The shelf life was extended to 180 days. The bleaching index was only 0.3. And the SO2 residue of fruit was only 3.1 mg/kg. Pulse anti-corrosion significantly improved the storage period and storage quality of red grape. This anti-corrosion method solves the industrial problems of unbalanced SO2 release, high fruit bleaching rate and high SO2 residue of traditional preservative paper.