The work aims to study the influences of the structure of honeycomb core and the static stress on the main resonance frequency of the paper honeycomb sandwich plate-block system. The vibration transmissibility of the paper honeycomb sandwich plate-block system was measured by sine vibration test, and the change rules of the main resonance frequencies of paper honeycomb sandwich plate-block system with different honeycomb cores under different static stresses were analyzed. The main resonance frequencies of the paper honeycomb sandwich plate-block system varied from 150 Hz to 350 Hz. The structure and material of honeycomb core had influence on the stiffness of paper honeycomb sandwich plate, which changed the main resonance frequency of the system. The change of block mass caused the change of static stress and affected the main resonance frequency of the system. The main resonance frequency decreased with the increase in the cell length of honeycomb, the paperboard thickness, the core paper grammage, and the static stress. A foundation is provided for the research of vibration transmissibility of paper honeycomb sandwich plate, thus promoting the optimization design of the honeycomb sandwich plates with different materials.