The work aims to study the effect of Micro-fibrillated Cellulose (MFC) and oxidized cassava starch on inkjet printing performance. Six groups of surface sizing agent were prepared by changing the ratio of MFC to oxidized cassava starch. The effect of oxidized cassava starch and MFC on inkjet printing performance was studied through the analysis of water absorption, dynamic permeability, gloss and printing quality of paper before and after sizing. When the oven dry mass ratio of oxidized cassava starch to MFC was 100∶1, the glossiness, whiteness and color density of the sized paper were higher, which overcame the shortcomings of ink bleaching to a great extent and improved the quality of text obviously. Compared with MFC sizing alone, the inkjet printing effect of MFC and oxidized cassava starch on color inkjet printing paper is better.