The work aims to prepare a natural edible starch-based film with antimicrobial activity. The ginger residue-corn starch film was prepared by the casting method with the corn starch as the raw material, added with an appropriate amount of ginger residue, glycerol and sodium carboxymethyl cellulose (CMC). When the mass fraction of starch was 3%, the mass fraction of glycerol was 1%, and the mass fraction of ginger residue was 0.4%, the comprehensive measurement results of the film's indexes were better, including transparency, oil permeability, water vapor permeability, solubility and swelling. The added ginger residue could be used as the natural antibacterial agent as the fresh ginger contained gingerol, ginger oil and other active ingredients. The results of microorganism experiment confirmed that ginger residue-corn starch film had certain bacteriostatic effect on aspergillus and yeast. Furthermore, the bacteriostatic effect was proportional to the content of ginger residue. Featured by a compact structure and smoothness, the prepared ginger residue-corn starch film has certain antimicrobial activity.