The work aims to study the law of effects of thickness and density on the static compression properties of expanded polypropylene foam by taking the expanded polypropylene foam as the research object. Through the static compression test, the load-displacement curves of different density and thickness were obtained. Then, the stress-strain curves, the energy absorption efficiency curves, the specific energy absorption (Es) , the total energy absorption (Ea) and the crushing strength were obtained by further processing. The effects of density and thickness on the static compressive properties of expanded polypropylene foam were analyzed by these curves. The shapes of stress-strain curves of expanded polypropylene foam with different density and thickness were basically similar. When the thickness was constant, the total energy absorption, specific energy absorption and crushing strength increased with the increase of density. When the density was constant, the total energy absorption increased with the increase of thickness, and the specific energy absorption decreased with the increase of thickness. But, the effect of thickness on densification strain and crushing strength could be neglected. For the optimal design of buffer packaging, to prevent excessive packaging resulting in waste of resources or lack of packaging resulting in the packaged from being damaged, the effects of thickness and density of foam materials on the cushioning and energy absorbing properties should be fully considered, and then the optimal scheme can be selected according to the comparative test results.