The work aims to study the method of determining the key parameters of cold plate refrigerated truck and the influence of cold plate layout on the cooling effect. A split cold plate refrigerated truck was designed. The structure of the carriage, the cooling mode, the size of the cold plate and the power of the refrigerating unit were determined. The finite volume method was used to analyze and compare the influence of different cold plate layouts at the pre-cooling state on the temperature field inside the carriage. After 30 min pre-cooling, the center position temperature of the carriage was 2.9 ℃ if the cold plate was placed at the top and side. The center temperature of the carriage was 10.1 ℃ if the cold plate was placed on the top. The quality utilization coefficient of the truck is improved by the split type cooling mode. The method of determining the parameters and the analysis method of temperature field can provide some basis for the design of cold plate refrigerated truck.