The work aims to compare and analyze the repeatability and stability of solvent residuals in printed matters by optimizing the conditions for printing technology of water-based ink. Select parallel samples randomly from different production serial-numbers but same production process and production batch, then determine solvent residuals by headspace-gas chromatography/mass spectrometry (HS-GC/MS). While the absolute deviation of other components was less than 0.1 mg/m2, the absolute deviation of ethanol and n-propyl acetate was greater than 0.1 mg/m2, but their relative deviations was less than 10%, which demonstrated the satisfactory repeatability. Under the same classification and different car numbers, the total amount of the four kinds of solvent residuals was far below the index value, which illustrated the stability was good. Water-based ink can not only meet the requirements of environmental printing, but also avoid the problem of excessive solvent residuals.