The work aims to prepare a TPU/PVDC co-extrusion film with high barrier, flame retardancy, antistatic property and wear resistance. According to the material characteristics of PVDC and TPU, and the performance and application requirements of the co-extrusion film of two materials, the TPU/PVDC five-layer co-extrusion film structure was designed and the TPU material was modified to make the co-extrusion film have good flame retardancy and antistatic ability. The co-extrusion composite technology was applied to reasonably design and prepare the technological process, and control the processing temperature and processing agent proportion in each area of the PVDC extruder in the process, so as to solve the technical problems of easy decomposition due to heating in PVDC processing. Through the optimal design of co-extrusion composite technology, the thickness of the prepared TPU/PVDC five-layer co-extrusion film was 154.3 μm, the moisture permeability could reach 0.88 g/(m2•d), the flame retardancy could reach the national standard FV-0 grade, the tearing strength of the film was 43 N, and it could not be peeled completely. The problems regarding the thermal decomposition in the PVDC co-extrusion and the modification of flame retardancy and antistatic property of TPU resin are effectively solved. The prepared high-barrier TPU/PVDC co-extrusion film has excellent performance in moisture permeability, thickness, width, flame retardancy, antistatic property and strength. It provides technical support for the development of high-barrier composite sealing material.