The work aims to conduct organic-inorganic modification of nano-TiO2 to keep the original anti-UV properties and reduce the photocatalytic activity, so as to realize the anti-aging protection of paper-based materials. Sol-gel method was applied to prepare SiO2 coatings on the surface of nano-TiO2 with tetraethoxysilane (TEOS) as precursor and then silane coupling agent of γ-(Methacryloxypropyl) trimethoxy Silane (KH570) was used for organic modification to prepare inorganic-organic composite particles. The sample was characterized and analyzed by Scanning electron microscopy (SEM), Transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray Diffraction (XRD) and Ultraviolet-visible spectroscopy (UV-Vis). The influence of TEOS dosage on the microstructure, UV resistance and photocatalysis performance of composite particles was explored. The modified SiO2 was successfully coated on the surface of nano-TiO2 in amorphous state and bonded as Si-O-Ti. The dispersibility of composite particles was improved obviously. The coating thickness was related to TEOS dosage. With the increase of TEOS dosage, the photocatalytic property of composite particles was significantly decreased, while the UV resistance capability almost remained the same. The composite modification of nano-TiO2 reduces its photocatalytic activity, but has little effect on its UV resistance, which is very beneficial to its application in the anti-aging protection solution of paper cultural relics.