The work aims to study how to determine the tolerance for brand color reproduction and the %Reproducible Pantone Colors of CMYK device. Beginning with the ICC-based color management workflow, the color difference among the color conversion process, reproduction process and measuring instrument was studied. Combined with the theory of vision, the influence coefficient and data used to determine the color tolerance of brand color reproduction were given. The tolerance for brand color reproduction was 3.5∆E00. The reproducible Pantone colors in CGATS21_CRPC5, CGATS21_CRPC6 and CGATS21_CRPC7 printing con-ditions converted by designated ICC Profile were 65%, 74% and 86%, respectively. The proposed method for determining the brand color reproduction tolerance can be used by a printing standardization body to quantitatively evaluate the reproducible brand colors of any color output device.